10,000 Salmonella Genomes Project

A worldwide effort to understand the epidemiology, transmission and virulence of invasive non-Typhoidal Salmonellosis.

The 10,000 Salmonella genomes project is an international collaborative effort led by Jay Hinton (University of Liverpool) and Neil Hall (Earlham Institute) and funded by the RCUK Global Challenge Research Fund, to sequence invasive non-Typhoidal Salmonella from developing countries on the Development Co-operation Directorate (DAC) list of Official Development Assistance (ODA) recipients.

Rationale

Our first blog post, describing the launch of the 10k Salmonella Genomes Project.

Jay Hinton (University of Liverpool) and Neil Hall (Earlham Institute) have won financing from the RCUK Global Challenge Research Fund. This grant pays for the sequencing and basic bioinformatic analysis of 10,000 Salmonella genomes of Salmonella isolates from a range of developing countries in Africa and Latin America, including Colombia, Costa Rica, Gambia, Malawi, Mexico, South Africa and Uganda.

The 10,000 Salmonella genomes project is designed to generate information relevant to the epidemiology, drug resistance and virulence factors of Salmonellae using a whole-genome sequencing approach. We are interested in identifying representative strains using a combination of core genome-based phylogenetics, identification of antibiotic resistance genes and comparisons of the accessory genome (particularly plasmids and phages). Ultimately, we will select individual strains that represent the diversity and clinical repertoire of invasive non-typhoidal Salmonella, and we...

Project Collaborators

A full list of collaborators involved in the 10k Salmonella Genomes Project.

Catherine Wilson – UoL – UK

Chirs Parry – LSTM – UK

Cristiano Gallina Moreira...